Absorption, Distribution, Metabolism and Excretion of PPP Toxicants: Online-Training

Learning Outcomes:

• Learn how ADME studies fit within the framework of the various regulations and guidances
• Understand the design and conduct of key ADME studies
• Interpretation of ADME data for regulatory submission
• Use of ADME data to support other disciplines

Programme:

10:00 Welcome address by the organisers and introduction by the trainer

10:10 Introduction and overview of ADME studies in the context of Regulation 1107/2009 and relationship with other Guidance

• Data requirements under Regulation 1107/2009
• Interaction of ADME across other guidance associated with Regulation 1107/2009
• Overview of data generation to meet requirements

11:10 Short break

11:20 Design and conduct of in vivo ADME studies

• Single and multiple dose excretion balance
• Tissue distribution/depletion
• Pharmacokinetics

12:20 Questions and answers

12:30 Lunch break

13:30 Design and conduct of biotransformation studies

• Comparative in vitro metabolism
• Metabolite profiling
• Metabolite extraction and identification in vivo/in vitro

14:30 Short break

14:40 Interpretation of results

• Derivation of oral absorption value
• In vivo ADME studies
• Biotransformation studies

15:40 Questions and answers

16:00 End of the online training

Who should attend this training?

Professionals working in the fields of:

• Toxicology
• Ecotoxicology
• Exposure assessment
• Risk assessment
• Registration
• Regulatory & government affairs
• Monitoring & computer modelling

Sectors that should take part:

• Agrochemical industry
• Professional associations
• Consultancies